Las Positas College
Spring, 2008

Penguin doing somersaults

 Required materials  Ground Rules  Laboratory schedule
 Grading Policies  Lecture/Discussion schedule  Back to page 1

Biology 1: Introduction to Cell Biology

Prerequisites: Zoology 1 or Botany 1 or equivalent (completed with a grade of "C" or higher).

Strongly recommended Chemistry 1B or concurrent enrollment; Physics 2A or concurrent enrollment, and eligibility for English 1A or 52 A

Instructor: (Mrs.) Karen Pihl

Office Hours: 10:00-10:50 TTH in office 2151, 10:20-11:10 WF, in room 1806/1807; 11:15-12:05 W, in office 2151; or by appointment.

Phone No.: 510-424-1359. Leave a message on the machine, if I am not there.



Required Materials:

Campbell, N.A., Reece, J.B., Urry, L.,Cain, M.L., Wasserman, S.A.,Minorsky, P.V.,Jackson, R.B. Biology. 8th ed. San Francisco, CA: Pearson Benjamin Cummings; 2009. If you use the attached disc, you must return it with the book or you will not be able to sell back the book to the bookstore.

Bound Laboratory Notebook. (printed page numbers and carbonless, similar to Chemistry Laboratory Notebook. Belmont, CA: Brooks/Cole; 1998. used in Chem 1A/1B. $15.50

Scan-Tron answer sheets.

Recommended: (If you find study guides useful)

Campbell, N.A., Reece, J.B., Taylor, M.R. Study guide for biology. 8th. ed. San Francisco, CA: Pearson Benjamin Cummings; 2008.

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Grading Policies:

Your final grade in this course will be based on the scores of your examinations in the lecture/discussion portion (52%) and your performance in the laboratory portion (48%) as follows:

Category Percentage Points
 Hour Examinations

32% (16% each)


 Final Examination



 In-class Quizzes



 Lecture/Discussion Total



Category Percentage Points
 Hour Examinations

16% (8% each)


 Laboratory Quizzes 5%  6



 Field/Lab Reports



 Laboratory Total



Class Total:
Category Points
 Lecture/Discussion Total


 Laboratory Total


 Class Total


If you have earned 1140 points, you are guaranteed an A (90% + 1510); 1030 points guaranteed a B (80% + 150); 865 points guaranteed a C (65% + 150); 700 points guaranteed a D (50% + 150). All of these totals include the 150 points for laboratory attendance.

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Ground Rules:

Your letter grade for each item will be indicated when it is returned and posted on Blackboard. Three hour examinations in lecture will be given. If you take all three exams, your lowest score will be dropped. If you miss an exam, that is your lowest score. No make-up examinations will be given.

In-class quizzes are unannounced. You will be able to work with other classmates to answer the questions but not use your notes or the text. If you miss class, you will receive a zero for the quiz. These quizzes cannot be made up. The zeros add up, if you do not attend lecture.

Eight laboratory quizzes will be given. If you take all of the quizzes, your lowest two scores will be dropped. If you are late to class, you will miss the quiz. If you miss a quiz, that is your lowest score. No make-up quizzes will be given under any circumstances. Points are deducted for late laboratory and field reports. Reports are not accepted at all, if they are so late that they have been returned to the rest of the class. For you to receive full credit for the report, you must submit a hard copy to the instructor and a copy to before the class period in which it is due. For some laboratories you will be assigned to a group. You may work together and write a single report. All students in the group will receive the same grade. As a part of the report you will submit a work sheet signed by all members of the group indicating the work and share of the work each individual did on the assignment. You may also choose to write an individual report.

A maximum of 40 extra points may be earned by presenting oral reports (20 points each) to the rest of the class. A page of instructions on how to do these reports is attached. The complete articles for these reports must be shown to the instructor by 7:30 am on the due date for report approval. See the laboratory schedule for dates. The articles must be from a scientific magazine, journal or online journal. The article must be three pages long. Information from a web site is not acceptable. A page of instructions on how to do these reports is attached. Difficult articles and excellent presentations earn more points.

"Stars" may be earned for answering questions correctly in lecture or lab, excellence in laboratory technique and high quality drawings. Stars earn extra credit points at the end of the semester.

If you anticipate missing a laboratory examination or the final examination, please inform the instructor in advance. If you are ill and miss the final examination or a laboratory examination, you must contact the instructor that day (925-424-1359) and leave a phone number and a time when you can be reached. Failure to attend the final examination may result in an "F" grade, if arrangements are not made that day or before. Twenty points will be subtracted from each missed exam unless you can document you were under the care of a physician.

Completion of all laboratories is mandatory. You will not receive a passing grade in this class unless you complete all the labs or a paper in lieu of a lab. You must complete the fruit fly independent project. You must inform the instructor in advance if you know you will miss a lab. Missed laboratories must be made up within a week. The only times when labs may be made up are when the instructor is in the lab with another class or holding office hours in 1806 (Tuesday and Thursday, 2:00-5:00 pm) or the hour after your lab on Monday and Wednesday. Some labs can only be done on the scheduled day. If you miss one of these laboratories, a research paper will be assigned. No more than one laboratory may be made up during the semester unless extenuating circumstances exist. You are responsible for determining a time to make up the lab when the instructor will be present, that the supplies you need will be retained (you must arrange this with the Lab Technician). All make-up labs must be written up and turned in. You will receive an Incomplete grade for the class, if you have not completed all the labs. It will be your responsibility to obtain an extension of this grade from the Vice President of Student Services during the fall semester so that you may do the lab missed the following spring. This will delay your grade in Biology 1 for one full calendar year. Needless to say the best policy is to attend every class. The "I" will automatically change to an "F", if not cleared. You receive 150 points at the end of the semester, if you have attended every lab and the field trip. If you miss a lab or leave the lab early, five points will be deducted. Making up the lab will NOT gain you the five points. Arriving late for the lab will result in a deduction of 2 points. Attendance is generally taken during the last half hour of lab.

Several of the experiments in this class will require laboratory work at unscheduled times. You should NOT expect all of the experiments to be finished in the three-hour laboratory period and to adjust your schedule accordingly. This is typical of the real world of scientific research. The fruit fly project is conducted almost entirely outside of class time.

If you are absent for a total of four consecutive or six cumulative instructional hours and/or two consecutive weeks, you may be dropped from the class unless you have explained your absences to the instructor.

Dropping the class. If you decide not to continue in the class, use CLASS-Web or go to Admissions and Records and drop yourself. You do not need to involve the instructor. Do not assume that the instructor will drop you for not attending the class.

If your behavior is disruptive or immature, you will be asked to leave the class and to see the instructor before returning. If the behavior continues, the Division Dean will be notified. If you are caught cheating (copying the lab report or data of another student, copying test or quiz answers, copying answers to questions in lab reports, not citing sources of information, copying material from a book or the internet), a report may be submitted to the Vice President of Student Services for investigation and disciplinary action. If you either give your lab report to another student or copy a lab report or portions of it, you will receive a zero for it. If you copy quiz or test answers from another student, or change answers on a returned quiz/exam/lab report, you will receive a zero for that activity.

Manners and success tips. Be on time. Don't come in late and slam the door or scrape your chair on the floor. Enter quietly. Come to every class and laboratory. Sit in the front of the room. Read all of the assignments. It is especially important to read the labs in advance. Take notes and read them as soon as possible after each class. Make an outline of the important points in the lecture. Clarify what you do not understand--come to office hours, send an email, form a study group, sign up for a tutor in the Assessment and Tutorial Center (1000). Resist the urge to fall asleep. Not only will you not learn anything while snoozing, but also it really annoys the instructor (something you want to avoid). Bring something to write with and on. Bring Scan-Tron sheets on days when we have quizzes or exams. Make sure your pencil is sharpened before the instructor begins. Bring and eraser.

Safety goggles are mandatory for certain laboratories. Some are available in the lab or you may bring the goggles you use for chemistry. They must fit tightly to your face. Shoes with closed toes and heels must be worn in the lab even during lecture. No food or beverages may be consumed in the lab even during the lecture. This includes water. Nothing by mouth in the labs (no fingers in mouth or eyes--contact replacement, taking medication, etc). Nothing may be placed down the drains, but water (and hand & dish detergents/soaps). Nothing should be placed into the regular trash cans, but paper towels from hand-washing and clean office paper.

You may use your laboratory notebook for the lab practicals but not the lab quizzes. It is in your best interest to keep a well organized and complete notebook. No material may be stapled or taped in. No pages may be removed. Everything must be hand written in ink. To receive credit for the fly experiment all of your activities must be documented in your notebook. Notebooks will periodically examined by the instructor and/or the carbons collected.

The field trip may conflict with another Friday class. Please contact me if you need to request permission from a faculty member to miss all or part of a class and to make up that time. Remember that this is a favor requested from another faculty member and not a demand. It may not always be possible to make up another class.

Cell phones must be put away during lecture and lab. Having your phone ring, reading your messages or text messaging during class may result in 20 points being deducted from your total accumuated points.

You may not eat or drink anything in the laboratory room or 1806, including water. On lecture and laboratory days you must wear shoes with closed toes and heels or you will not be allowed to enter the lab.


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(Subject to Modification)

 Week of Topic  Text Chapter
1/22-1/29 The Cell  6, pp. 3-10
 2/5-2/12 How Things Enter and Leave Cells. Cell Communication  7, 11
**2/8 **Last Day for NGR in person. 2/10 Last day for NGR using Class-Web  
**2/14-2/18 **Holidays  
2/19 Some Chemistry. 4, 5
2/26 How Cells Obtain Useful Energy  8, 9
**2/26 **Hour Examination # 1  6,7,11,4,5, pp. 3-10
3/4 How Cells Divide. Meiosis  12, 13
3/11 Classical Genetics  14
3/18 Genes and Chromosomes  15
**3/24-3/28 **Holidays  
4/1 The Double Helix--DNA  16
**4/3 **Hour Examination #2  8-9, 12-15
4/8 How Cells Make Protein  17
**4/11 **Last Day for "W"  

Gene Regulation

4/22 Genome Organization, DNA Technology 20, 21
4/29 Origin of Life 25
5/1 **Hour Examination #3  16-18, 20, 21
5/6 Darwin, The Evidence  pp. 12-17, 22
5/13 Microevolution  23
5/20 The Origin of Species, Macroevolution  24
**5/29 ** Final Examination 7:30-9:20 AM  

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(Subject to Modification)
Highly recommended - Read the lab in advance
 Date  Topic Lab Separate Text Chapter Reference

Introduction. Safety, Scientific Method.
Videotape - Scientific Methods and Values (MV22242)

The Northern Elephant Seal

Videotape - Elephant Seals. Those Magnificent Diving Machines (MV 21254)

  pp. 18-24
 1/25 The Microscope, Demonstration of Phase Contrast Microscope and Fluorescent Microscope.
Videotape - Living Cells (VMV 20996)

Light Microscopy (6002)


pp. 94-97
 1/30 Cell Structure.
Cell Structure and Function. (6003) Subcellular Structure and Function (6004) ch. 6

Introduction to genetics - corn genetics.
Begin Non Mendelian Genetics: Maternal Inheritance of Variegation. Plant variegated seeds.
Videotape - Discovering the Cell (VMV 21340)

QUIZ #1. This quiz contains information from the web about Ano Nuevo and seals.

Mendelian Genetics (6010-corn). Handout (non Mendelian Genetics)


ch. 14, pp. 300-302
 2/6 Bioluminescence. Thin Brassica plants to one per cell. Plant green seeds. Select variegated plants. Make bee sticks. Handout Bioluminescence (Adams #44) pp. 142, 156, 570-571, 672

Field Trip to Ano Nuevo State Reserve
Departure time is 10:30 AM
Estimated Return - 6:00 PM
You are expected to attend this field trip and are responsible for material concerning it. You must be in the barn at the Reserve by 12:30 PM or you will miss the tour.
There is a $6.00 parking fee and you must pay the San Mateo Bridge toll ($4.00). If it is not possible for you to attend, a library research paper will be assigned. You must let me know in advance if you will not be coming or 15 points will be deducted from you total. Bring food for yourself. None is available at the Reserve. Wear walking shoes. Bring rain gear and warm clothes. Umbrellas are not allowed

 2/13 Drosophila Genetics. Place barrier between Brassica plants.
Pollinate Brassica. Determine corn results.
Mendelian Genetics (6010) Introduction to Culturing Fruit Flies (Adams #22)  ch. 14
2/15 Holiday    

Cell Permeability, Discussion of Results
Pollinate Brassica


Handout (Cell Permeability)  ch. 7
 2/22 Cell Permeability (continued). Pollinate Brassica
Introduction to Plant Cell Culture
(Edvotek-# 908)
Handout (Introduction to Plant Cell Culture) ch. 7, pp. 241-242, 814-815
 2/27 Analysis of a Cell-Surface Receptor
(Modern Biology Exp-702)
Handout (Analysis of a Cell-Surface Receptor) ch. 11, p. 130

Analysis of a Cell-Surface Receptor (continued). Discussion of Results.


 3/5 Biologically Important
Molecules: Proteins
Discussion of Results
Video-Tape - Proteins - Their Structure and Function (MV21138, pt. 12)
Biologically Important Molecules (6001), (Adams #41) pp. 77-86
 3/7 Biologically Important Molecules: Carbohydrates and Lipids
Discussion of Results
Biologically Important Molecules (6001), 41 pp. 69-77

Laboratory Examination #1, 8:30 AM

Stop watering Brassica


Activity of an Enzyme. Potato peroxidase for the study of enzyme properties.
Deadline for approval of extra-credit report articles is at the beginning of lab (7:30 AM)

Handout Activity of an Enzyme (Adams #5 ) pp. 151-156
 3/19 Respiration Measurement.
Collect Brassica seeds.
Handout (Measurement of Respiration) ch. 9

Cellular Reproduction. Mitosis. Preparation of onion root tip chromosomes (old 848 - new 39)

Genetics Problems

Extra-Credit Oral Reports

Cellular Reproduction (6005), Chromosome Studies (Adams #39 ) ch. 12
3/26, 3/28 Holidays    
 4/1** Begin Human Chromosome Investigation.
7:30 AM. Class time will not be available to begin this experiment.
NOTE - This is a Tuesday
Chromosome Studies (Adams #39)  

Cellular Reproduction. Meiosis.

Videotape - Generations: Mitosis and Meiosis (MV22267).

Cellular Reproduction (6005)  ch. 13
 4/4 Human Chromosomes.
Karyotyping (Carolina # 173832).

Chromosome Studies (Adams #39 )


pp. 250, 299

Genetics and Sickle Cell Anemia
(Modern Biology # 102) .
Discussion of Results.

Plant second generation of Brassica.

Genetics and Sickle Cell Anemia (Adams # 38 ) pp. 85, 278, 344, 405-406
4/11 Chromosomal Basis of Heredity.
Preparation of salivary gland chromosomes. Barr Bodies. (old 848--new 39)
Chromosomal Basis of Heredity (6011), Chromosome Studies (Adams #39 ) p. 292
4/16 Human Genetics
Count green/variegated plants. Compile Brassica data.
Human Genetics (6012) ch. 14

Extraction of DNA.
Videotape - The Genetic Code (MV 21138, pt. 12)


Nucleic Acids: The Quest for DNA (Adams #45) ch. 16
 4/23 Human DNA Fingerprinting by PCR (BioRad PV92 PCR Informatics Kit 166-2100EDU ) Handout PV92 PCR Informatics Kit p. 403-404, 419-420
 4/25 PCR (Continued). Photograph results    
 4/30 DNA Restriction Analysis (Carolina)
Videotape - The Brain Eater (MV22877)
Handout DNA Restriction and Analysis (Adams #40) ch. 20
 5/2 DNA Restriction Analysis
Discussion of Results

Producing a Strain of E. coli that Glows in the Dark.
(Modern Biology Ind-9)

Quiz #7

Handout Producing a Strain of E. coli that Glows in the Dark. ch. 20
 5/9 Protein Fingerprinting Kit (BioRad 166-0100EDU)
Drosophila report due with flies.
Deadline for approval of extra-credit report articles is at the beginning of lab (7:30 AM).
Handout Protein Fingerprinting Kit. Is There Something Fishy About Teaching Evolution? pp. 540-542

The ELISA Immunoassay
(Modern Biology Ind-3)
Discussion of Results


Handout The ELISA Immunoassay pp. 945-946

Sequencing the Human Genome (Edvotek #339)

Extra-Credit Oral Reports

Handout Sequencing the Human Genome pp. 408-409
 5/21** Laboratory Examination #2 8:30 AM - -

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1. Select an article from a current (published within the last three years) periodical that relates to the course you are taking. (If you are in Botany, it should be about some botanical or ecological problem or principle.) Examples of periodicals in the Las Positas LRC that may be used are:

 Sample Periodicals:  
 American Forests National Geographic
 Audubon National Wildlife
 Bioscience Natural History
 California Wild Nature
 Chemical and Engineering News Nature Conservancy
 Discover Science
 Environment Scientific American
 JAMA Sierra

Livermore, Dublin and Pleasanton Libraries are also sources of science periodicals. EBSCO host is a good source of articles.

2. The article must be at least three pages long. Short newspaper articles are not acceptable, nor are articles from popular magazines such as Reader's Digest, Muscle and Fitness, Good Housekeeping. Online journals or periodicals from the internet may be used; however, you may not give a report simply about information from a particular website. Acceptable sites should have a date and volume. Typically the word "journal" is in the title. If you are not certain, ask your instructor before the deadline date for approval.

3. Read the article to make certain you understand basically what it is about. (It is impossible to present an oral report on something that makes no sense to you.)

4. Bring the entire article (or a copy) to lab on or before the deadline date for approval. Your article must be approved by the instructor in advance. Articles are not accepted after the deadline.

5. You may use notes and audiovisual material. If you require media equipment, you need to inform the instructor one class period in advance of the presentation. Make certain before the day of the presentation that the computer will recognize and read your file. Save your presentation in an old version of PowerPoint if you have Office2007. Our computers have old software.

6. Your report should last 10-15 minutes. Make certain you announce the name of the article, author(s) and the date of the periodical.

7. No written material is to be turned in. This is not intended to be a research paper on a particular subject. Only one article is to be used.

8. Points are awarded based on the difficulty of the article, use of audiovisual materials and the quality of the presentation. Try not to simply read from your notes.

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